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Puppy Vaccination Schedule

Updated October 2026 · 5 min read · By MaunaPet

Published by MaunaPet. Editorial policy and sources.

AAHA includes leptospirosis among core canine vaccines. Ask your vet how current guidance applies to your location and puppy. AAHA.

Why Are Puppy Vaccinations So Important?

Vaccinating your puppy is one of the most critical steps you can take to ensure they grow up healthy and strong. When puppies are born, they receive temporary immunity from their mother's milk (colostrum). However, this maternal immunity fades within the first few weeks of life, leaving the puppy vulnerable to serious and potentially fatal infectious diseases.

Did you know? Maternal antibodies can interfere with early vaccinations, which is why puppies require a series of booster shots to build their own immune system.

Core vs. Non-Core Vaccines

Veterinarians categorize puppy vaccines into two main groups: core and non-core vaccines.

Core Vaccines

Core vaccines are recommended for all puppies, regardless of their location or lifestyle, due to the severity of the diseases they prevent.

Non-Core Vaccines

Non-core vaccines are administered based on your puppy's specific lifestyle, environment, and risk of exposure.

The Week-by-Week Puppy Vaccination Timeline

A puppy schedule is individualized. Combination vaccines usually start at 6–8 weeks and repeat every 2–4 weeks, with the final initial-series dose at 16 weeks or older. Your vet adapts the schedule and rabies vaccination to the product and local requirements. AAHA recommendations.

6 to 8 Weeks

At this age, puppies receive their first round of core vaccines. They are usually given the initial DHPP vaccine and, if recommended by the vet, the Bordetella vaccine.

10 to 12 Weeks

During this visit, your puppy will receive the second DHPP booster. Depending on their lifestyle, the vet may also administer the initial doses of additional vaccines such as leptospirosis or Lyme disease.

16 Weeks or Older

The final initial-series core dose should be at 16 weeks or older; some puppies need a longer series. Your vet determines rabies timing and other vaccinations based on risk and product guidance.

Stay on track with vaccines

Calculate the exact dates for your puppy's vaccination schedule.

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What to Expect After Vaccination

It is common for puppies to experience mild side effects after receiving a vaccine. These can include lethargy, a slight fever, or tenderness at the injection site. These symptoms typically resolve within 24 to 48 hours.

Important: If your puppy experiences facial swelling, vomiting, difficulty breathing, or severe hives, seek immediate veterinary care, as these could be signs of an allergic reaction.

When Can My Puppy Go Outside Safely?

It is generally safe to take your puppy outside in your own private, enclosed yard. However, you should avoid public spaces, dog parks, and areas where unvaccinated dogs may frequent until two weeks after their final round of core vaccines at 16 weeks of age.

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Sources and further reading

Links checked on October 1, 2026. These sources support the topic; they do not certify this entire article or tool. Consult your veterinarian for diagnosis and treatment.